Overview/Definition

Definition:
-• Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect comprising four components: large VSD, overriding aorta, right ventricular outflow tract (RVOT) obstruction, and right ventricular hypertrophy
-Accounts for 3-5% of all CHD and 10% of cyanotic CHD with excellent surgical outcomes when managed appropriately.
Epidemiology:
-• Incidence of 0.4-0.7 per 1000 live births in India with male predominance (1.3:1)
-Associated with chromosomal abnormalities: 22q11.2 deletion syndrome (15-20%), Down syndrome (8%), and CHARGE syndrome
-Maternal risk factors include diabetes, phenylketonuria, and rubella infection during pregnancy.
Age Distribution:
-• Clinical presentation varies with degree of RVOT obstruction: severe obstruction presents with cyanosis in neonatal period, moderate obstruction at 3-6 months, mild obstruction may remain asymptomatic until childhood
-Peak age for hypercyanotic spells is 6-24 months
-Optimal surgical age is 6-12 months.
Clinical Significance:
-• Essential high-yield topic for DNB Pediatrics and NEET SS focusing on spell management, surgical timing, and long-term complications
-Critical for understanding cyanotic CHD physiology, polycythemia consequences, and postoperative arrhythmia risks
-Key condition for pediatric emergency management protocols.

Age-Specific Considerations

Newborn:
-• Neonatal presentation depends on degree of pulmonary stenosis: severe obstruction causes early cyanosis and may require PGE infusion to maintain ductal patency
-Milder cases may appear pink initially
-Hypercyanotic spells rare in neonatal period due to higher hemoglobin oxygen affinity and smaller muscular component of RVOT.
Infant:
-• Peak period for hypercyanotic spells (6-24 months) due to increasing muscular component of RVOT obstruction and decreasing oxygen affinity of adult hemoglobin
-Squatting behavior typically develops after walking age
-Growth failure common due to chronic hypoxemia and increased metabolic demands
-Clubbing develops by 6-12 months.
Child:
-• Established cyanosis with exercise intolerance and squatting after exertion
-Risk of cerebral abscess, stroke, and endocarditis increases with age
-Polycythemia complications become prominent (hematocrit >65%)
-Delayed cognitive development possible due to chronic hypoxemia
-School activity restrictions necessary.
Adolescent:
-• Unoperated survivors develop severe complications: stroke risk, endocarditis, arrhythmias, and sudden cardiac death
-Pregnancy contraindicated in unrepaired females due to high maternal and fetal mortality
-Post-operative patients need lifelong cardiology follow-up for arrhythmias, pulmonary regurgitation, and sudden death risk.

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Clinical Presentation

Symptoms:
-• Central cyanosis present from birth or develops in infancy depending on RVOT severity
-Exercise intolerance with dyspnea, fatigue, and squatting after exertion
-Hypercyanotic spells: sudden onset severe cyanosis, irritability, dyspnea, and possible loss of consciousness
-Growth retardation and developmental delays in severe cases.
Physical Signs:
-• Central cyanosis with clubbing of fingers and toes
-Harsh systolic ejection murmur grade 3-4/6 at left sternal border (softer during spells)
-Right ventricular heave, single S2 heart sound
-Polycythemia signs: conjunctival injection, ruddy complexion
-Squatting posture to increase systemic vascular resistance.
Severity Assessment:
-• Mild TOF: Oxygen saturation >85%, minimal symptoms, normal growth
-Moderate TOF: Oxygen saturation 75-85%, exercise intolerance, some growth delay
-Severe TOF: Oxygen saturation <75%, frequent spells, significant growth failure, clubbing by 6 months, hematocrit >65%.
Differential Diagnosis:
-• Differential includes other cyanotic CHD: pulmonary atresia with VSD (no murmur, ductal dependent), tricuspid atresia (different murmur pattern), single ventricle lesions
-Acyanotic conditions with pulmonary stenosis and intact ventricular septum
-Pulmonary atresia with intact ventricular septum in neonates.

Diagnostic Approach

History Taking:
-• Detailed prenatal history including maternal diabetes, medications, infections
-Birth history and neonatal cyanosis onset
-Feeding pattern assessment and growth trajectory
-Detailed spell description: triggers, duration, interventions, frequency
-Exercise tolerance and developmental milestone achievement
-Family history of CHD.
Investigations:
-• Chest X-ray shows "boot-shaped" heart with decreased pulmonary markings, right aortic arch in 25%
-ECG demonstrates right axis deviation and right ventricular hypertrophy
-Echocardiography diagnostic showing all four components, RVOT gradient assessment, and branch pulmonary artery anatomy.
Normal Values:
-• Normal oxygen saturation >95% (TOF typically 70-85%)
-Normal hemoglobin: neonates 14-20g/dL, infants 10-14g/dL, children 11-13g/dL (TOF often >16g/dL)
-Normal RVOT gradient <30mmHg (TOF typically 40-100mmHg)
-Normal RV systolic pressure <30mmHg (TOF elevated).
Interpretation:
-• RVOT gradient assessment: mild <40mmHg, moderate 40-70mmHg, severe >70mmHg correlates with cyanosis severity
-Branch pulmonary artery anatomy critical for surgical planning
-Aortopulmonary collateral assessment important in severe cases
-Coronary anatomy evaluation essential before surgery (LAD from RCA in 5-10%).

Management/Treatment

Acute Management:
-• Hypercyanotic spell management: knee-chest position, oxygen, IV morphine 0.1mg/kg, IV propranolol 0.01-0.25mg/kg, phenylephrine 5-10mcg/kg IV if hypotensive
-Volume expansion with normal saline 10ml/kg
-Consider bicarbonate if severe acidosis
-Emergency Blalock-Taussig shunt if medical management fails.
Chronic Management:
-• Medical management until surgery: propranolol 0.5-1mg/kg TID to prevent spells, iron supplementation to maintain hemoglobin 16-18g/dL, avoid dehydration and fever
-Surgical options: complete intracardiac repair (ICR) preferred at 6-12 months, Blalock-Taussig shunt as bridge in neonates with severe symptoms.
Lifestyle Modifications:
-• Activity restriction appropriate for oxygen saturation: mild TOF may participate in non-competitive sports, severe TOF requires significant limitation
-Hydration maintenance crucial especially during febrile illness
-Avoid hot environments and prolonged crying
-Air travel precautions with supplemental oxygen if saturation <85%.
Follow Up:
-• Pre-operative: every 1-3 months depending on severity with echocardiography, CBC, and growth assessment
-Post-operative: lifelong follow-up annually with ECG, echocardiography, and Holter monitoring
-Exercise testing after adolescence
-Genetic counseling for affected families (3-5% recurrence risk).

Age-Specific Dosing

Medications:
-• Propranolol: Neonates 0.25mg/kg TID, Infants 0.5mg/kg TID, Children 1mg/kg TID (max 40mg TID)
-Morphine for spells: 0.05-0.1mg/kg IV (neonates lower dose)
-Phenylephrine: 5-10mcg/kg IV bolus
-Iron supplementation: 3-6mg/kg/day elemental iron divided BID-TID.
Formulations:
-• Propranolol available as 10mg, 40mg tablets and 4mg/mL oral solution
-Morphine 1mg/mL injection for emergency use
-Iron sulfate drops 25mg/mL elemental iron for infants, tablets for older children
-Phenylephrine 10mg/mL injection for hospital use only.
Safety Considerations:
-• Propranolol monitoring: heart rate >100 bpm in infants, >80 bpm in children, avoid in asthma or severe heart failure
-Morphine respiratory depression risk especially in cyanotic patients
-Iron supplementation: GI upset, constipation, overdose toxicity
-Avoid decongestants and stimulants.
Monitoring:
-• Regular CBC monitoring for polycythemia (target hematocrit 55-65%), iron studies every 3-6 months
-Growth parameters monthly in infants
-Oxygen saturation monitoring at rest and with activity
-Blood pressure and heart rate monitoring on propranolol therapy
-Renal function if on ACE inhibitors.

Prevention & Follow-up

Prevention Strategies:
-• Primary prevention limited as most TOF cases are sporadic
-Periconceptional folic acid supplementation may reduce overall CHD risk
-Maternal diabetes control important during organogenesis
-Avoid teratogenic medications including thalidomide, phenytoin, and alcohol during pregnancy.
Vaccination Considerations:
-• Standard immunization schedule with additional influenza vaccine annually
-Pneumococcal vaccination important due to functional asplenia risk
-Live vaccines generally safe in post-operative patients without immunosuppression
-COVID-19 vaccination recommended as high-risk group
-RSV prophylaxis in select high-risk infants.
Follow Up Schedule:
-• Pre-operative: monthly in symptomatic infants, every 3 months in stable patients
-Post-operative: 1 week, 1 month, 6 months, then annually lifelong
-More frequent follow-up for arrhythmias, heart failure, or other complications
-Transition to adult congenital heart disease specialist by age 16-18.
Monitoring Parameters:
-• Growth velocity and developmental milestones
-Exercise tolerance using age-appropriate functional assessment
-Hemoglobin and hematocrit levels for polycythemia monitoring
-Echocardiographic assessment of residual defects, ventricular function, and valve regurgitation
-ECG and Holter for arrhythmia detection.

Complications

Acute Complications:
-• Hypercyanotic spells most dangerous acute complication, can lead to seizures, stroke, or death if untreated
-Cerebral abscess risk due to right-to-left shunting bypassing pulmonary filter
-Dehydration rapidly worsens cyanosis due to increased blood viscosity
-Infective endocarditis risk especially with poor dental hygiene.
Chronic Complications:
-• Polycythemia complications: stroke, seizures, bleeding tendency, gout
-Eisenmenger syndrome in unrepaired cases with progressive pulmonary hypertension
-Post-operative complications: arrhythmias (10-15%), sudden cardiac death (1-2%), pulmonary regurgitation requiring valve replacement, residual VSD.
Warning Signs:
-• Spell indicators: increased cyanosis, irritability, hyperpnea followed by lethargy or loss of consciousness
-Neurological symptoms: headache, confusion, focal deficits suggesting cerebral complications
-Bleeding tendency with severe polycythemia
-Fever or new murmur suggesting endocarditis.
Emergency Referral:
-• Immediate referral for hypercyanotic spells not responding to initial management
-New onset neurological symptoms or signs of stroke
-Suspected endocarditis with fever and new murmur
-Severe dehydration or illness requiring hospitalization
-Any sudden deterioration in exercise tolerance or consciousness.

Parent Education Points

Counseling Points:
-• Explain TOF as "four heart problems together" causing mixing of blue and red blood
-Emphasize excellent surgical outcomes with >95% survival and good quality of life
-Discuss spell recognition and immediate management techniques
-Address activity limitations and gradual improvement after surgery
-Provide genetic counseling for family planning.
Home Care:
-• Spell management: place child in knee-chest position, remain calm, provide comfort
-Maintain adequate hydration especially during illness or hot weather
-Monitor for signs of dehydration: decreased urination, dry mouth, lethargy
-Ensure adequate rest and avoid overexertion
-Maintain good dental hygiene to prevent endocarditis.
Medication Administration:
-• Give propranolol with food at consistent times, monitor for slow heart rate or breathing
-Iron supplements between meals for better absorption, with vitamin C if tolerated
-Never stop cardiac medications abruptly without consulting cardiologist
-Keep emergency medications (morphine) readily available if prescribed.
When To Seek Help:
-• Call 911 for spell lasting >15 minutes, loss of consciousness, or seizure activity
-Seek immediate care for: sudden increase in cyanosis, severe breathing difficulty, neurological changes, high fever >38.5°C
-Contact cardiologist for: decreased exercise tolerance, new symptoms, missed medications >24 hours, or any parental concerns about child's condition.